Learn More About Clinical Trials

Find out more about the safe guards in place, what the various phases mean and what goes on in a study.

Watch Our 2 Minute Video


Clinical Studies

Local Duchenne Muscular Dystrophy (Dmd) Study

It is studying Duchenne Muscular Dystrophy (Dmd)

Learn More

Transpyloric Feeding in Severe Bronchopulmonary Dysplasia

It is studying Bronchopulmonary Dysplasia

Learn More

The Chimerix CMX001 Registry

It is studying Outcomes , Survival Rates

Learn More

RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR

It is studying Mitochondrial Myopathies

Learn More

Versartis Long-Acting Growth Hormone in Children Compared to Daily rhGH

It is studying Growth Disorders

Learn More

Evaluation of the AMICUS RBCx System in Sickle Cell Patients

It is studying Sickle Cell Anemia

Learn More

Study of VTS-270 (2-hydroxypropyl-β-cyclodextrin) to Treat Niemann-Pick Type C1 (NPC1) Disease

It is studying Niemann-Pick Disease, Type C

Learn More

Domperidone Expanded Access Protocol for Patients With Gastrointestinal Disorders

It is studying Refractory Gastroesophageal Reflux Disease With Upper Gastrointestinal (Gi) Symptoms, Gastroparesis, And Chronic Constipation

Learn More

Communication to Improve Shared Decision-Making in ADHD

It is studying Attention-Deficit/Hyperactivity Disorder

Learn More

Low Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) Therapy

It is studying Pediatric Crohn'S Disease

Learn More

Promoting Intrafamily Accountability for Reducing Cellphone Use While Driving in Adults and Their Teen Children

It is studying Teen Drivers , Motor Vehicle Accidents

Learn More

Logo

We aim educate everyone about clinical research while making it easier to find nearby trials.

Patients

Researchers

Contact Us

19200 Von Karmen Avenue, Suite 600
Irvine, California, US

Patients Call: (855) 255-7049
Email: patients@trialjoin.com
Whoops! There was an error.
ErrorException (E_WARNING)
file_put_contents(): Only 0 of 244 bytes written, possibly out of free disk space ErrorException thrown with message "file_put_contents(): Only 0 of 244 bytes written, possibly out of free disk space" Stacktrace: #7 ErrorException in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122 #6 file_put_contents in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122 #5 Illuminate\Filesystem\Filesystem:put in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php:83 #4 Illuminate\Session\FileSessionHandler:write in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Session/Store.php:128 #3 Illuminate\Session\Store:save in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php:87 #2 Illuminate\Session\Middleware\StartSession:terminate in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php:218 #1 Illuminate\Foundation\Http\Kernel:terminateMiddleware in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php:189 #0 Illuminate\Foundation\Http\Kernel:terminate in /var/www/trialjoin/public/index.php:60
Application frames (1) All frames (8)
7
ErrorException
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Filesystem
/
Filesystem.php
122
6
file_put_contents
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Filesystem
/
Filesystem.php
122
5
Illuminate
\
Filesystem
\
Filesystem
put
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
FileSessionHandler.php
83
4
Illuminate
\
Session
\
FileSessionHandler
write
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
Store.php
128
3
Illuminate
\
Session
\
Store
save
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
Middleware
/
StartSession.php
87
2
Illuminate
\
Session
\
Middleware
\
StartSession
terminate
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Http
/
Kernel.php
218
1
Illuminate
\
Foundation
\
Http
\
Kernel
terminateMiddleware
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Http
/
Kernel.php
189
0
Illuminate
\
Foundation
\
Http
\
Kernel
terminate
…
/
public
/
index.php
60
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Filesystem
/
Filesystem.php
 
     *
     * @param  string  $path
     * @return string
     */
    public function hash($path)
    {
        return md5_file($path);
    }
 
    /**
     * Write the contents of a file.
     *
     * @param  string  $path
     * @param  string  $contents
     * @param  bool  $lock
     * @return int
     */
    public function put($path, $contents, $lock = false)
    {
        return file_put_contents($path, $contents, $lock ? LOCK_EX : 0);
    }
 
    /**
     * Prepend to a file.
     *
     * @param  string  $path
     * @param  string  $data
     * @return int
     */
    public function prepend($path, $data)
    {
        if ($this->exists($path)) {
            return $this->put($path, $data.$this->get($path));
        }
 
        return $this->put($path, $data);
    }
 
    /**
     * Append to a file.
Arguments 
  1. "file_put_contents(): Only 0 of 244 bytes written, possibly out of free disk space"
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Filesystem
/
Filesystem.php
 
     *
     * @param  string  $path
     * @return string
     */
    public function hash($path)
    {
        return md5_file($path);
    }
 
    /**
     * Write the contents of a file.
     *
     * @param  string  $path
     * @param  string  $contents
     * @param  bool  $lock
     * @return int
     */
    public function put($path, $contents, $lock = false)
    {
        return file_put_contents($path, $contents, $lock ? LOCK_EX : 0);
    }
 
    /**
     * Prepend to a file.
     *
     * @param  string  $path
     * @param  string  $data
     * @return int
     */
    public function prepend($path, $data)
    {
        if ($this->exists($path)) {
            return $this->put($path, $data.$this->get($path));
        }
 
        return $this->put($path, $data);
    }
 
    /**
     * Append to a file.
Arguments 
  1. "/var/www/trialjoin/storage/framework/sessions/SgxgFZvrBjPhKq98eYWaOD38J9our1U9Q15NUUDK"

  2. "a:3:{s:6:"_token";s:40:"BzhoYLZm2aWJWrPAMAOQazGv3MbpS6rRgZqaHycI";s:9:"_previous";a:1:{s:3:"url";s:86:"https://trialjoin.com/cstudies?search_text=Duchenne%20Muscular%20Dystrophy%20%28Dmd%29";}s:6:"_flash";a:2:{s:3:"old";a:0:{}s:3:"new";a:0:{}}}"

  3. 2
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
FileSessionHandler.php
 
    /**
     * {@inheritdoc}
     */
    public function read($sessionId)
    {
        if ($this->files->exists($path = $this->path.'/'.$sessionId)) {
            if (filemtime($path) >= Carbon::now()->subMinutes($this->minutes)->getTimestamp()) {
                return $this->files->get($path, true);
            }
        }
 
        return '';
    }
 
    /**
     * {@inheritdoc}
     */
    public function write($sessionId, $data)
    {
        $this->files->put($this->path.'/'.$sessionId, $data, true);
 
        return true;
    }
 
    /**
     * {@inheritdoc}
     */
    public function destroy($sessionId)
    {
        $this->files->delete($this->path.'/'.$sessionId);
 
        return true;
    }
 
    /**
     * {@inheritdoc}
     */
    public function gc($lifetime)
    {
        $files = Finder::create()
Arguments 
  1. "/var/www/trialjoin/storage/framework/sessions/SgxgFZvrBjPhKq98eYWaOD38J9our1U9Q15NUUDK"

  2. "a:3:{s:6:"_token";s:40:"BzhoYLZm2aWJWrPAMAOQazGv3MbpS6rRgZqaHycI";s:9:"_previous";a:1:{s:3:"url";s:86:"https://trialjoin.com/cstudies?search_text=Duchenne%20Muscular%20Dystrophy%20%28Dmd%29";}s:6:"_flash";a:2:{s:3:"old";a:0:{}s:3:"new";a:0:{}}}"

  3. true
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
Store.php
 
     *
     * @param  string  $data
     * @return string
     */
    protected function prepareForUnserialize($data)
    {
        return $data;
    }
 
    /**
     * Save the session data to storage.
     *
     * @return bool
     */
    public function save()
    {
        $this->ageFlashData();
 
        $this->handler->write($this->getId(), $this->prepareForStorage(
            serialize($this->attributes)
        ));
 
        $this->started = false;
    }
 
    /**
     * Prepare the serialized session data for storage.
     *
     * @param  string  $data
     * @return string
     */
    protected function prepareForStorage($data)
    {
        return $data;
    }
 
    /**
     * Age the flash data for the session.
     *
     * @return void
Arguments 
  1. "SgxgFZvrBjPhKq98eYWaOD38J9our1U9Q15NUUDK"

  2. "a:3:{s:6:"_token";s:40:"BzhoYLZm2aWJWrPAMAOQazGv3MbpS6rRgZqaHycI";s:9:"_previous";a:1:{s:3:"url";s:86:"https://trialjoin.com/cstudies?search_text=Duchenne%20Muscular%20Dystrophy%20%28Dmd%29";}s:6:"_flash";a:2:{s:3:"old";a:0:{}s:3:"new";a:0:{}}}"
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
Middleware
/
StartSession.php
 
        if ($this->sessionConfigured()) {
            $this->storeCurrentUrl($request, $session);
 
            $this->addCookieToResponse($response, $session);
        }
 
        return $response;
    }
 
    /**
     * Perform any final actions for the request lifecycle.
     *
     * @param  \Illuminate\Http\Request  $request
     * @param  \Symfony\Component\HttpFoundation\Response  $response
     * @return void
     */
    public function terminate($request, $response)
    {
        if ($this->sessionHandled && $this->sessionConfigured() && ! $this->usingCookieSessions()) {
            $this->manager->driver()->save();
        }
    }
 
    /**
     * Start the session for the given request.
     *
     * @param  \Illuminate\Http\Request  $request
     * @return \Illuminate\Contracts\Session\Session
     */
    protected function startSession(Request $request)
    {
        return tap($this->getSession($request), function ($session) use ($request) {
            $session->setRequestOnHandler($request);
 
            $session->start();
        });
    }
 
    /**
     * Get the session implementation from the manager.
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Http
/
Kernel.php
 
     * @return void
     */
    protected function terminateMiddleware($request, $response)
    {
        $middlewares = $this->app->shouldSkipMiddleware() ? [] : array_merge(
            $this->gatherRouteMiddleware($request),
            $this->middleware
        );
 
        foreach ($middlewares as $middleware) {
            if (! is_string($middleware)) {
                continue;
            }
 
            list($name) = $this->parseMiddleware($middleware);
 
            $instance = $this->app->make($name);
 
            if (method_exists($instance, 'terminate')) {
                $instance->terminate($request, $response);
            }
        }
    }
 
    /**
     * Gather the route middleware for the given request.
     *
     * @param  \Illuminate\Http\Request  $request
     * @return array
     */
    protected function gatherRouteMiddleware($request)
    {
        if ($route = $request->route()) {
            return $this->router->gatherRouteMiddleware($route);
        }
 
        return [];
    }
 
    /**
Arguments 
  1. Request {
  #json: null
  #convertedFiles: null
  #userResolver: Closure {
    class: "Illuminate\Auth\AuthServiceProvider"
    this: AuthServiceProvider { …}
    parameters: {
      $guard: {
        default: null
      }
    }
    use: {
      $app: Application { …}
    }
  }
  #routeResolver: Closure {
    class: "Illuminate\Routing\Router"
    this: Router { …}
    use: {
      $route: Route { …}
    }
  }
  +attributes: ParameterBag {}
  +request: ParameterBag {#1}
  +query: ParameterBag {#1}
  +server: ServerBag {}
  +files: FileBag {}
  +cookies: ParameterBag {}
  +headers: HeaderBag {}
  #content: null
  #languages: null
  #charsets: null
  #encodings: null
  #acceptableContentTypes: array:4 [
    0 => "text/html"
    1 => "application/xhtml+xml"
    2 => "application/xml"
    3 => "*/*"
  ]
  #pathInfo: "/cstudies"
  #requestUri: "/cstudies?search_text=Duchenne%20Muscular%20Dystrophy%20(Dmd)"
  #baseUrl: ""
  #basePath: null
  #method: "GET"
  #format: null
  #session: Store {}
  #locale: null
  #defaultLocale: "en"
  -isHostValid: true
  -isForwardedValid: true
  basePath: ""
  format: "html"
}

  2. Response {}
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Http
/
Kernel.php
 
     */
    protected function dispatchToRouter()
    {
        return function ($request) {
            $this->app->instance('request', $request);
 
            return $this->router->dispatch($request);
        };
    }
 
    /**
     * Call the terminate method on any terminable middleware.
     *
     * @param  \Illuminate\Http\Request  $request
     * @param  \Illuminate\Http\Response  $response
     * @return void
     */
    public function terminate($request, $response)
    {
        $this->terminateMiddleware($request, $response);
 
        $this->app->terminate();
    }
 
    /**
     * Call the terminate method on any terminable middleware.
     *
     * @param  \Illuminate\Http\Request  $request
     * @param  \Illuminate\Http\Response  $response
     * @return void
     */
    protected function terminateMiddleware($request, $response)
    {
        $middlewares = $this->app->shouldSkipMiddleware() ? [] : array_merge(
            $this->gatherRouteMiddleware($request),
            $this->middleware
        );
 
        foreach ($middlewares as $middleware) {
            if (! is_string($middleware)) {
Arguments 
  1. Request {
  #json: null
  #convertedFiles: null
  #userResolver: Closure {
    class: "Illuminate\Auth\AuthServiceProvider"
    this: AuthServiceProvider { …}
    parameters: {
      $guard: {
        default: null
      }
    }
    use: {
      $app: Application { …}
    }
  }
  #routeResolver: Closure {
    class: "Illuminate\Routing\Router"
    this: Router { …}
    use: {
      $route: Route { …}
    }
  }
  +attributes: ParameterBag {}
  +request: ParameterBag {#1}
  +query: ParameterBag {#1}
  +server: ServerBag {}
  +files: FileBag {}
  +cookies: ParameterBag {}
  +headers: HeaderBag {}
  #content: null
  #languages: null
  #charsets: null
  #encodings: null
  #acceptableContentTypes: array:4 [
    0 => "text/html"
    1 => "application/xhtml+xml"
    2 => "application/xml"
    3 => "*/*"
  ]
  #pathInfo: "/cstudies"
  #requestUri: "/cstudies?search_text=Duchenne%20Muscular%20Dystrophy%20(Dmd)"
  #baseUrl: ""
  #basePath: null
  #method: "GET"
  #format: null
  #session: Store {}
  #locale: null
  #defaultLocale: "en"
  -isHostValid: true
  -isForwardedValid: true
  basePath: ""
  format: "html"
}

  2. Response {}
/
var
/
www
/
trialjoin
/
public
/
index.php
 
|--------------------------------------------------------------------------
| Run The Application
|--------------------------------------------------------------------------
|
| Once we have the application, we can handle the incoming request
| through the kernel, and send the associated response back to
| the client's browser allowing them to enjoy the creative
| and wonderful application we have prepared for them.
|
*/
 
$kernel = $app->make(Illuminate\Contracts\Http\Kernel::class);
 
$response = $kernel->handle(
    $request = Illuminate\Http\Request::capture()
);
 
$response->send();
 
$kernel->terminate($request, $response);
Arguments 
  1. Request {
  #json: null
  #convertedFiles: null
  #userResolver: Closure {
    class: "Illuminate\Auth\AuthServiceProvider"
    this: AuthServiceProvider { …}
    parameters: {
      $guard: {
        default: null
      }
    }
    use: {
      $app: Application { …}
    }
  }
  #routeResolver: Closure {
    class: "Illuminate\Routing\Router"
    this: Router { …}
    use: {
      $route: Route { …}
    }
  }
  +attributes: ParameterBag {}
  +request: ParameterBag {#1}
  +query: ParameterBag {#1}
  +server: ServerBag {}
  +files: FileBag {}
  +cookies: ParameterBag {}
  +headers: HeaderBag {}
  #content: null
  #languages: null
  #charsets: null
  #encodings: null
  #acceptableContentTypes: array:4 [
    0 => "text/html"
    1 => "application/xhtml+xml"
    2 => "application/xml"
    3 => "*/*"
  ]
  #pathInfo: "/cstudies"
  #requestUri: "/cstudies?search_text=Duchenne%20Muscular%20Dystrophy%20(Dmd)"
  #baseUrl: ""
  #basePath: null
  #method: "GET"
  #format: null
  #session: Store {}
  #locale: null
  #defaultLocale: "en"
  -isHostValid: true
  -isForwardedValid: true
  basePath: ""
  format: "html"
}

  2. Response {}

Environment & details:

Key Value
search_text 
"Duchenne Muscular Dystrophy (Dmd)"
empty
empty
empty
empty
Key Value
REDIRECT_HTTPS 
"on"
REDIRECT_SSL_TLS_SNI 
"trialjoin.com"
REDIRECT_STATUS 
"200"
HTTPS 
"on"
SSL_TLS_SNI 
"trialjoin.com"
SSL_SERVER_S_DN_CN 
"*.trialjoin.com"
SSL_SERVER_I_DN_C 
"US"
SSL_SERVER_I_DN_O 
"DigiCert Inc"
SSL_SERVER_I_DN_OU 
"www.digicert.com"
SSL_SERVER_I_DN_CN 
"GeoTrust TLS RSA CA G1"
SSL_SERVER_SAN_DNS_0 
"*.trialjoin.com"
SSL_SERVER_SAN_DNS_1 
"trialjoin.com"
SSL_VERSION_INTERFACE 
"mod_ssl/2.4.18"
SSL_VERSION_LIBRARY 
"OpenSSL/1.0.2g"
SSL_PROTOCOL 
"TLSv1.2"
SSL_SECURE_RENEG 
"true"
SSL_COMPRESS_METHOD 
"NULL"
SSL_CIPHER 
"ECDHE-RSA-AES256-SHA"
SSL_CIPHER_EXPORT 
"false"
SSL_CIPHER_USEKEYSIZE 
"256"
SSL_CIPHER_ALGKEYSIZE 
"256"
SSL_CLIENT_VERIFY 
"NONE"
SSL_SERVER_M_VERSION 
"3"
SSL_SERVER_M_SERIAL 
"0483C36ACDF14162FEFD91BE08CDD241"
SSL_SERVER_V_START 
"Dec 28 00:00:00 2017 GMT"
SSL_SERVER_V_END 
"Jan 27 12:00:00 2019 GMT"
SSL_SERVER_S_DN 
"CN=*.trialjoin.com"
SSL_SERVER_I_DN 
"CN=GeoTrust TLS RSA CA G1,OU=www.digicert.com,O=DigiCert Inc,C=US"
SSL_SERVER_A_KEY 
"rsaEncryption"
SSL_SERVER_A_SIG 
"sha256WithRSAEncryption"
SSL_SESSION_ID 
"12b07333b349cdefe1d4001d898365cfb0682d6da826f0d14aecd72aa2d904b0"
SSL_SESSION_RESUMED 
"Initial"
HTTP_USER_AGENT 
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_ACCEPT 
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_IF_MODIFIED_SINCE 
"Thu, 18 Oct 2018 13:30:37 UTC"
HTTP_HOST 
"trialjoin.com"
HTTP_CONNECTION 
"Keep-Alive"
HTTP_ACCEPT_ENCODING 
"gzip"
PATH 
"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin"
SERVER_SIGNATURE 
"<address>Apache/2.4.18 (Ubuntu) Server at trialjoin.com Port 443</address>\n"
SERVER_SOFTWARE 
"Apache/2.4.18 (Ubuntu)"
SERVER_NAME 
"trialjoin.com"
SERVER_ADDR 
"192.241.173.169"
SERVER_PORT 
"443"
REMOTE_ADDR 
"54.226.36.60"
DOCUMENT_ROOT 
"/var/www/trialjoin/public"
REQUEST_SCHEME 
"https"
CONTEXT_PREFIX 
""
CONTEXT_DOCUMENT_ROOT 
"/var/www/trialjoin/public"
SERVER_ADMIN 
"webmaster@localhost"
SCRIPT_FILENAME 
"/var/www/trialjoin/public/index.php"
REMOTE_PORT 
"49224"
REDIRECT_URL 
"/cstudies"
REDIRECT_QUERY_STRING 
"search_text=Duchenne%20Muscular%20Dystrophy%20(Dmd)"
GATEWAY_INTERFACE 
"CGI/1.1"
SERVER_PROTOCOL 
"HTTP/1.1"
REQUEST_METHOD 
"GET"
QUERY_STRING 
"search_text=Duchenne%20Muscular%20Dystrophy%20(Dmd)"
REQUEST_URI 
"/cstudies?search_text=Duchenne%20Muscular%20Dystrophy%20(Dmd)"
SCRIPT_NAME 
"/index.php"
PHP_SELF 
"/index.php"
REQUEST_TIME_FLOAT 
1544510293.151
REQUEST_TIME 
1544510293
APP_NAME 
"Laravel"
APP_ENV 
"local"
APP_KEY 
"base64:Y6eAJzTDbYfZK6VMvJM4WneK1MJXADTUWotu9WAGd94="
APP_DEBUG 
"true"
APP_LOG_LEVEL 
"debug"
APP_URL 
"http://localhost"
BROADCAST_DRIVER 
"log"
CACHE_DRIVER 
"file"
SESSION_DRIVER 
"file"
QUEUE_DRIVER 
"sync"
REDIS_HOST 
"127.0.0.1"
REDIS_PASSWORD 
"null"
REDIS_PORT 
"6379"
MAIL_DRIVER 
"smtp"
MAIL_HOST 
"smtp.mailtrap.io"
MAIL_PORT 
"2525"
MAIL_USERNAME 
"null"
MAIL_PASSWORD 
"null"
MAIL_ENCRYPTION 
"null"
PUSHER_APP_ID 
""
PUSHER_APP_KEY 
""
PUSHER_APP_SECRET 
""
Key Value
APP_NAME 
"Laravel"
APP_ENV 
"local"
APP_KEY 
"base64:Y6eAJzTDbYfZK6VMvJM4WneK1MJXADTUWotu9WAGd94="
APP_DEBUG 
"true"
APP_LOG_LEVEL 
"debug"
APP_URL 
"http://localhost"
BROADCAST_DRIVER 
"log"
CACHE_DRIVER 
"file"
SESSION_DRIVER 
"file"
QUEUE_DRIVER 
"sync"
REDIS_HOST 
"127.0.0.1"
REDIS_PASSWORD 
"null"
REDIS_PORT 
"6379"
MAIL_DRIVER 
"smtp"
MAIL_HOST 
"smtp.mailtrap.io"
MAIL_PORT 
"2525"
MAIL_USERNAME 
"null"
MAIL_PASSWORD 
"null"
MAIL_ENCRYPTION 
"null"
PUSHER_APP_ID 
""
PUSHER_APP_KEY 
""
PUSHER_APP_SECRET 
""
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