Learn More About Clinical Trials

Find out more about the safe guards in place, what the various phases mean and what goes on in a study.

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Clinical Studies

Local Pulmonary Hypertension Study

It is studying Pulmonary Hypertension

Learn More

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

It is studying Interstitial Lung Disease , Pulmonary Hypertension , Combined Pulmonary Fibrosis And Emphysema

Learn More

MIF- Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial Hypertension

It is studying Interstitial Lung Disease , Pulmonary Hypertension , Pulmonary Arterial Hypertension

Learn More

Vedolizumab IV in Pediatric Participants With Ulcerative Colitis or Crohn's Disease

It is studying Crohn'S Disease , Ulcerative Colitis

Learn More

VENUS: Septic Gene Expression Using SeptiCyte

It is studying Sepsis , Sepsis , Systemic Inflammatory Response Syndrome (Sirs)

Learn More

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

It is studying Interstitial Lung Disease , Pulmonary Hypertension , Combined Pulmonary Fibrosis And Emphysema

Learn More

Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction

It is studying Ventricular Tachycardia , Ventricular Fibrillation , Ventricular Fibrillation , Low Cardiac Output , Low Cardiac Output

Learn More

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

It is studying Interstitial Lung Disease , Pulmonary Hypertension , Combined Pulmonary Fibrosis And Emphysema

Learn More

Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation

It is studying Pulmonary Hypertension

Learn More

Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation

It is studying Pulmonary Hypertension

Learn More

Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation

It is studying Pulmonary Hypertension

Learn More

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We aim educate everyone about clinical research while making it easier to find nearby trials.

Patients

Researchers

Contact Us

19200 Von Karmen Avenue, Suite 600
Irvine, California, US

Patients Call: (855) 255-7049
Email: patients@trialjoin.com
Whoops! There was an error.
ErrorException (E_WARNING)
file_put_contents(): Only 0 of 225 bytes written, possibly out of free disk space ErrorException thrown with message "file_put_contents(): Only 0 of 225 bytes written, possibly out of free disk space" Stacktrace: #7 ErrorException in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122 #6 file_put_contents in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122 #5 Illuminate\Filesystem\Filesystem:put in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php:83 #4 Illuminate\Session\FileSessionHandler:write in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Session/Store.php:128 #3 Illuminate\Session\Store:save in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php:87 #2 Illuminate\Session\Middleware\StartSession:terminate in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php:218 #1 Illuminate\Foundation\Http\Kernel:terminateMiddleware in /var/www/trialjoin/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php:189 #0 Illuminate\Foundation\Http\Kernel:terminate in /var/www/trialjoin/public/index.php:60
Application frames (1) All frames (8)
7
ErrorException
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Filesystem
/
Filesystem.php
122
6
file_put_contents
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Filesystem
/
Filesystem.php
122
5
Illuminate
\
Filesystem
\
Filesystem
put
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
FileSessionHandler.php
83
4
Illuminate
\
Session
\
FileSessionHandler
write
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
Store.php
128
3
Illuminate
\
Session
\
Store
save
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
Middleware
/
StartSession.php
87
2
Illuminate
\
Session
\
Middleware
\
StartSession
terminate
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Http
/
Kernel.php
218
1
Illuminate
\
Foundation
\
Http
\
Kernel
terminateMiddleware
…
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Http
/
Kernel.php
189
0
Illuminate
\
Foundation
\
Http
\
Kernel
terminate
…
/
public
/
index.php
60
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Filesystem
/
Filesystem.php
 
     *
     * @param  string  $path
     * @return string
     */
    public function hash($path)
    {
        return md5_file($path);
    }
 
    /**
     * Write the contents of a file.
     *
     * @param  string  $path
     * @param  string  $contents
     * @param  bool  $lock
     * @return int
     */
    public function put($path, $contents, $lock = false)
    {
        return file_put_contents($path, $contents, $lock ? LOCK_EX : 0);
    }
 
    /**
     * Prepend to a file.
     *
     * @param  string  $path
     * @param  string  $data
     * @return int
     */
    public function prepend($path, $data)
    {
        if ($this->exists($path)) {
            return $this->put($path, $data.$this->get($path));
        }
 
        return $this->put($path, $data);
    }
 
    /**
     * Append to a file.
Arguments 
  1. "file_put_contents(): Only 0 of 225 bytes written, possibly out of free disk space"
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Filesystem
/
Filesystem.php
 
     *
     * @param  string  $path
     * @return string
     */
    public function hash($path)
    {
        return md5_file($path);
    }
 
    /**
     * Write the contents of a file.
     *
     * @param  string  $path
     * @param  string  $contents
     * @param  bool  $lock
     * @return int
     */
    public function put($path, $contents, $lock = false)
    {
        return file_put_contents($path, $contents, $lock ? LOCK_EX : 0);
    }
 
    /**
     * Prepend to a file.
     *
     * @param  string  $path
     * @param  string  $data
     * @return int
     */
    public function prepend($path, $data)
    {
        if ($this->exists($path)) {
            return $this->put($path, $data.$this->get($path));
        }
 
        return $this->put($path, $data);
    }
 
    /**
     * Append to a file.
Arguments 
  1. "/var/www/trialjoin/storage/framework/sessions/REinLNICapjATFhC66F713UiCgEtPNFPI30lctdT"

  2. "a:3:{s:6:"_token";s:40:"bTMVtPzFp6pMQCvonNizxDN7xECjnbJlgvQcE4yj";s:9:"_previous";a:1:{s:3:"url";s:67:"https://trialjoin.com/cstudies?search_text=Pulmonary%20Hypertension";}s:6:"_flash";a:2:{s:3:"old";a:0:{}s:3:"new";a:0:{}}}"

  3. 2
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
FileSessionHandler.php
 
    /**
     * {@inheritdoc}
     */
    public function read($sessionId)
    {
        if ($this->files->exists($path = $this->path.'/'.$sessionId)) {
            if (filemtime($path) >= Carbon::now()->subMinutes($this->minutes)->getTimestamp()) {
                return $this->files->get($path, true);
            }
        }
 
        return '';
    }
 
    /**
     * {@inheritdoc}
     */
    public function write($sessionId, $data)
    {
        $this->files->put($this->path.'/'.$sessionId, $data, true);
 
        return true;
    }
 
    /**
     * {@inheritdoc}
     */
    public function destroy($sessionId)
    {
        $this->files->delete($this->path.'/'.$sessionId);
 
        return true;
    }
 
    /**
     * {@inheritdoc}
     */
    public function gc($lifetime)
    {
        $files = Finder::create()
Arguments 
  1. "/var/www/trialjoin/storage/framework/sessions/REinLNICapjATFhC66F713UiCgEtPNFPI30lctdT"

  2. "a:3:{s:6:"_token";s:40:"bTMVtPzFp6pMQCvonNizxDN7xECjnbJlgvQcE4yj";s:9:"_previous";a:1:{s:3:"url";s:67:"https://trialjoin.com/cstudies?search_text=Pulmonary%20Hypertension";}s:6:"_flash";a:2:{s:3:"old";a:0:{}s:3:"new";a:0:{}}}"

  3. true
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
Store.php
 
     *
     * @param  string  $data
     * @return string
     */
    protected function prepareForUnserialize($data)
    {
        return $data;
    }
 
    /**
     * Save the session data to storage.
     *
     * @return bool
     */
    public function save()
    {
        $this->ageFlashData();
 
        $this->handler->write($this->getId(), $this->prepareForStorage(
            serialize($this->attributes)
        ));
 
        $this->started = false;
    }
 
    /**
     * Prepare the serialized session data for storage.
     *
     * @param  string  $data
     * @return string
     */
    protected function prepareForStorage($data)
    {
        return $data;
    }
 
    /**
     * Age the flash data for the session.
     *
     * @return void
Arguments 
  1. "REinLNICapjATFhC66F713UiCgEtPNFPI30lctdT"

  2. "a:3:{s:6:"_token";s:40:"bTMVtPzFp6pMQCvonNizxDN7xECjnbJlgvQcE4yj";s:9:"_previous";a:1:{s:3:"url";s:67:"https://trialjoin.com/cstudies?search_text=Pulmonary%20Hypertension";}s:6:"_flash";a:2:{s:3:"old";a:0:{}s:3:"new";a:0:{}}}"
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Session
/
Middleware
/
StartSession.php
 
        if ($this->sessionConfigured()) {
            $this->storeCurrentUrl($request, $session);
 
            $this->addCookieToResponse($response, $session);
        }
 
        return $response;
    }
 
    /**
     * Perform any final actions for the request lifecycle.
     *
     * @param  \Illuminate\Http\Request  $request
     * @param  \Symfony\Component\HttpFoundation\Response  $response
     * @return void
     */
    public function terminate($request, $response)
    {
        if ($this->sessionHandled && $this->sessionConfigured() && ! $this->usingCookieSessions()) {
            $this->manager->driver()->save();
        }
    }
 
    /**
     * Start the session for the given request.
     *
     * @param  \Illuminate\Http\Request  $request
     * @return \Illuminate\Contracts\Session\Session
     */
    protected function startSession(Request $request)
    {
        return tap($this->getSession($request), function ($session) use ($request) {
            $session->setRequestOnHandler($request);
 
            $session->start();
        });
    }
 
    /**
     * Get the session implementation from the manager.
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Http
/
Kernel.php
 
     * @return void
     */
    protected function terminateMiddleware($request, $response)
    {
        $middlewares = $this->app->shouldSkipMiddleware() ? [] : array_merge(
            $this->gatherRouteMiddleware($request),
            $this->middleware
        );
 
        foreach ($middlewares as $middleware) {
            if (! is_string($middleware)) {
                continue;
            }
 
            list($name) = $this->parseMiddleware($middleware);
 
            $instance = $this->app->make($name);
 
            if (method_exists($instance, 'terminate')) {
                $instance->terminate($request, $response);
            }
        }
    }
 
    /**
     * Gather the route middleware for the given request.
     *
     * @param  \Illuminate\Http\Request  $request
     * @return array
     */
    protected function gatherRouteMiddleware($request)
    {
        if ($route = $request->route()) {
            return $this->router->gatherRouteMiddleware($route);
        }
 
        return [];
    }
 
    /**
Arguments 
  1. Request {
  #json: null
  #convertedFiles: null
  #userResolver: Closure {
    class: "Illuminate\Auth\AuthServiceProvider"
    this: AuthServiceProvider { …}
    parameters: {
      $guard: {
        default: null
      }
    }
    use: {
      $app: Application { …}
    }
  }
  #routeResolver: Closure {
    class: "Illuminate\Routing\Router"
    this: Router { …}
    use: {
      $route: Route { …}
    }
  }
  +attributes: ParameterBag {}
  +request: ParameterBag {#1}
  +query: ParameterBag {#1}
  +server: ServerBag {}
  +files: FileBag {}
  +cookies: ParameterBag {}
  +headers: HeaderBag {}
  #content: null
  #languages: null
  #charsets: null
  #encodings: null
  #acceptableContentTypes: array:4 [
    0 => "text/html"
    1 => "application/xhtml+xml"
    2 => "application/xml"
    3 => "*/*"
  ]
  #pathInfo: "/cstudies"
  #requestUri: "/cstudies?search_text=Pulmonary%20Hypertension"
  #baseUrl: ""
  #basePath: null
  #method: "GET"
  #format: null
  #session: Store {}
  #locale: null
  #defaultLocale: "en"
  -isHostValid: true
  -isForwardedValid: true
  basePath: ""
  format: "html"
}

  2. Response {}
/
var
/
www
/
trialjoin
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Http
/
Kernel.php
 
     */
    protected function dispatchToRouter()
    {
        return function ($request) {
            $this->app->instance('request', $request);
 
            return $this->router->dispatch($request);
        };
    }
 
    /**
     * Call the terminate method on any terminable middleware.
     *
     * @param  \Illuminate\Http\Request  $request
     * @param  \Illuminate\Http\Response  $response
     * @return void
     */
    public function terminate($request, $response)
    {
        $this->terminateMiddleware($request, $response);
 
        $this->app->terminate();
    }
 
    /**
     * Call the terminate method on any terminable middleware.
     *
     * @param  \Illuminate\Http\Request  $request
     * @param  \Illuminate\Http\Response  $response
     * @return void
     */
    protected function terminateMiddleware($request, $response)
    {
        $middlewares = $this->app->shouldSkipMiddleware() ? [] : array_merge(
            $this->gatherRouteMiddleware($request),
            $this->middleware
        );
 
        foreach ($middlewares as $middleware) {
            if (! is_string($middleware)) {
Arguments 
  1. Request {
  #json: null
  #convertedFiles: null
  #userResolver: Closure {
    class: "Illuminate\Auth\AuthServiceProvider"
    this: AuthServiceProvider { …}
    parameters: {
      $guard: {
        default: null
      }
    }
    use: {
      $app: Application { …}
    }
  }
  #routeResolver: Closure {
    class: "Illuminate\Routing\Router"
    this: Router { …}
    use: {
      $route: Route { …}
    }
  }
  +attributes: ParameterBag {}
  +request: ParameterBag {#1}
  +query: ParameterBag {#1}
  +server: ServerBag {}
  +files: FileBag {}
  +cookies: ParameterBag {}
  +headers: HeaderBag {}
  #content: null
  #languages: null
  #charsets: null
  #encodings: null
  #acceptableContentTypes: array:4 [
    0 => "text/html"
    1 => "application/xhtml+xml"
    2 => "application/xml"
    3 => "*/*"
  ]
  #pathInfo: "/cstudies"
  #requestUri: "/cstudies?search_text=Pulmonary%20Hypertension"
  #baseUrl: ""
  #basePath: null
  #method: "GET"
  #format: null
  #session: Store {}
  #locale: null
  #defaultLocale: "en"
  -isHostValid: true
  -isForwardedValid: true
  basePath: ""
  format: "html"
}

  2. Response {}
/
var
/
www
/
trialjoin
/
public
/
index.php
 
|--------------------------------------------------------------------------
| Run The Application
|--------------------------------------------------------------------------
|
| Once we have the application, we can handle the incoming request
| through the kernel, and send the associated response back to
| the client's browser allowing them to enjoy the creative
| and wonderful application we have prepared for them.
|
*/
 
$kernel = $app->make(Illuminate\Contracts\Http\Kernel::class);
 
$response = $kernel->handle(
    $request = Illuminate\Http\Request::capture()
);
 
$response->send();
 
$kernel->terminate($request, $response);
Arguments 
  1. Request {
  #json: null
  #convertedFiles: null
  #userResolver: Closure {
    class: "Illuminate\Auth\AuthServiceProvider"
    this: AuthServiceProvider { …}
    parameters: {
      $guard: {
        default: null
      }
    }
    use: {
      $app: Application { …}
    }
  }
  #routeResolver: Closure {
    class: "Illuminate\Routing\Router"
    this: Router { …}
    use: {
      $route: Route { …}
    }
  }
  +attributes: ParameterBag {}
  +request: ParameterBag {#1}
  +query: ParameterBag {#1}
  +server: ServerBag {}
  +files: FileBag {}
  +cookies: ParameterBag {}
  +headers: HeaderBag {}
  #content: null
  #languages: null
  #charsets: null
  #encodings: null
  #acceptableContentTypes: array:4 [
    0 => "text/html"
    1 => "application/xhtml+xml"
    2 => "application/xml"
    3 => "*/*"
  ]
  #pathInfo: "/cstudies"
  #requestUri: "/cstudies?search_text=Pulmonary%20Hypertension"
  #baseUrl: ""
  #basePath: null
  #method: "GET"
  #format: null
  #session: Store {}
  #locale: null
  #defaultLocale: "en"
  -isHostValid: true
  -isForwardedValid: true
  basePath: ""
  format: "html"
}

  2. Response {}

Environment & details:

Key Value
search_text 
"Pulmonary Hypertension"
empty
empty
empty
empty
Key Value
REDIRECT_HTTPS 
"on"
REDIRECT_SSL_TLS_SNI 
"trialjoin.com"
REDIRECT_STATUS 
"200"
HTTPS 
"on"
SSL_TLS_SNI 
"trialjoin.com"
SSL_SERVER_S_DN_CN 
"*.trialjoin.com"
SSL_SERVER_I_DN_C 
"US"
SSL_SERVER_I_DN_O 
"DigiCert Inc"
SSL_SERVER_I_DN_OU 
"www.digicert.com"
SSL_SERVER_I_DN_CN 
"GeoTrust TLS RSA CA G1"
SSL_SERVER_SAN_DNS_0 
"*.trialjoin.com"
SSL_SERVER_SAN_DNS_1 
"trialjoin.com"
SSL_VERSION_INTERFACE 
"mod_ssl/2.4.18"
SSL_VERSION_LIBRARY 
"OpenSSL/1.0.2g"
SSL_PROTOCOL 
"TLSv1.2"
SSL_SECURE_RENEG 
"true"
SSL_COMPRESS_METHOD 
"NULL"
SSL_CIPHER 
"ECDHE-RSA-AES256-SHA"
SSL_CIPHER_EXPORT 
"false"
SSL_CIPHER_USEKEYSIZE 
"256"
SSL_CIPHER_ALGKEYSIZE 
"256"
SSL_CLIENT_VERIFY 
"NONE"
SSL_SERVER_M_VERSION 
"3"
SSL_SERVER_M_SERIAL 
"0483C36ACDF14162FEFD91BE08CDD241"
SSL_SERVER_V_START 
"Dec 28 00:00:00 2017 GMT"
SSL_SERVER_V_END 
"Jan 27 12:00:00 2019 GMT"
SSL_SERVER_S_DN 
"CN=*.trialjoin.com"
SSL_SERVER_I_DN 
"CN=GeoTrust TLS RSA CA G1,OU=www.digicert.com,O=DigiCert Inc,C=US"
SSL_SERVER_A_KEY 
"rsaEncryption"
SSL_SERVER_A_SIG 
"sha256WithRSAEncryption"
SSL_SESSION_ID 
"3742f418e33abda7ead73c039bead65da33baf506f7690a6991bb68c776c6544"
SSL_SESSION_RESUMED 
"Initial"
HTTP_USER_AGENT 
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_ACCEPT 
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_IF_MODIFIED_SINCE 
"Fri, 19 Oct 2018 22:28:52 GMT"
HTTP_HOST 
"trialjoin.com"
HTTP_CONNECTION 
"Keep-Alive"
HTTP_ACCEPT_ENCODING 
"gzip"
PATH 
"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin"
SERVER_SIGNATURE 
"<address>Apache/2.4.18 (Ubuntu) Server at trialjoin.com Port 443</address>\n"
SERVER_SOFTWARE 
"Apache/2.4.18 (Ubuntu)"
SERVER_NAME 
"trialjoin.com"
SERVER_ADDR 
"192.241.173.169"
SERVER_PORT 
"443"
REMOTE_ADDR 
"54.167.15.6"
DOCUMENT_ROOT 
"/var/www/trialjoin/public"
REQUEST_SCHEME 
"https"
CONTEXT_PREFIX 
""
CONTEXT_DOCUMENT_ROOT 
"/var/www/trialjoin/public"
SERVER_ADMIN 
"webmaster@localhost"
SCRIPT_FILENAME 
"/var/www/trialjoin/public/index.php"
REMOTE_PORT 
"34856"
REDIRECT_URL 
"/cstudies"
REDIRECT_QUERY_STRING 
"search_text=Pulmonary%20Hypertension"
GATEWAY_INTERFACE 
"CGI/1.1"
SERVER_PROTOCOL 
"HTTP/1.1"
REQUEST_METHOD 
"GET"
QUERY_STRING 
"search_text=Pulmonary%20Hypertension"
REQUEST_URI 
"/cstudies?search_text=Pulmonary%20Hypertension"
SCRIPT_NAME 
"/index.php"
PHP_SELF 
"/index.php"
REQUEST_TIME_FLOAT 
1544708755.765
REQUEST_TIME 
1544708755
APP_NAME 
"Laravel"
APP_ENV 
"local"
APP_KEY 
"base64:Y6eAJzTDbYfZK6VMvJM4WneK1MJXADTUWotu9WAGd94="
APP_DEBUG 
"true"
APP_LOG_LEVEL 
"debug"
APP_URL 
"http://localhost"
BROADCAST_DRIVER 
"log"
CACHE_DRIVER 
"file"
SESSION_DRIVER 
"file"
QUEUE_DRIVER 
"sync"
REDIS_HOST 
"127.0.0.1"
REDIS_PASSWORD 
"null"
REDIS_PORT 
"6379"
MAIL_DRIVER 
"smtp"
MAIL_HOST 
"smtp.mailtrap.io"
MAIL_PORT 
"2525"
MAIL_USERNAME 
"null"
MAIL_PASSWORD 
"null"
MAIL_ENCRYPTION 
"null"
PUSHER_APP_ID 
""
PUSHER_APP_KEY 
""
PUSHER_APP_SECRET 
""
Key Value
APP_NAME 
"Laravel"
APP_ENV 
"local"
APP_KEY 
"base64:Y6eAJzTDbYfZK6VMvJM4WneK1MJXADTUWotu9WAGd94="
APP_DEBUG 
"true"
APP_LOG_LEVEL 
"debug"
APP_URL 
"http://localhost"
BROADCAST_DRIVER 
"log"
CACHE_DRIVER 
"file"
SESSION_DRIVER 
"file"
QUEUE_DRIVER 
"sync"
REDIS_HOST 
"127.0.0.1"
REDIS_PASSWORD 
"null"
REDIS_PORT 
"6379"
MAIL_DRIVER 
"smtp"
MAIL_HOST 
"smtp.mailtrap.io"
MAIL_PORT 
"2525"
MAIL_USERNAME 
"null"
MAIL_PASSWORD 
"null"
MAIL_ENCRYPTION 
"null"
PUSHER_APP_ID 
""
PUSHER_APP_KEY 
""
PUSHER_APP_SECRET 
""
0. Whoops\Handler\PrettyPageHandler